Pathological and clinical analysis of minimal change primary nephritic syndrome with tubulointerstitial lesions in children

Abstract:

Objective：To investigate clinical and pathological characteristics of minimal change primary nephrotic syndrome（MCN） with tubulointerstitial lesions（TIL） in children. Methods：Pathological and clinical materials of 148 patients with MCN were retrospec－tively analyzed，and clinical and pathological characteristics of MCN with TIL were compared. Results：A total of 28 patients had TIL，accounting for 18.9%；the main pathological changes of TIL were inflammatory cell infiltration and tubule dilatation. The condition of children in the TIL group were more severe than that in the non-TIL group，with manifestations such as hematuria，increased protein excretion，renal inadequacy，and significantly impaired tubule function，indicating that renal function damage was closely related to development of TIL. MCN outcome was not obviously associated with TIL（P>0.05）. Conclusion：With the occurrence of TIL，the con－dition of children with MCN is aggravated，indicating that TIL may be an important factor influencing the progression of MCN.