Research advances in invasion mechanism and inhibitors of 2019-nCoV

Abstract:

The pathogen was identified as a new type of coronavirus and named as 2019-nCoV. The nucleic acids and encoded viral proteins of 2019-nCoV and SARS-CoV are highly homologous，indicating that their biological functions may also be very similar. 2019-nCoV uses the S1 subunit of its spike protein binding to the ACE2 receptor on the surface of the host cell，and uses the host protease to cleave the S protein to promote membrane fusion and then endocytosis. Inhibitors that blocking 2019-nCoV invasion can be divided into neutralizing antibody/receptor inhibitors，protease inhibitors，and endocytosis regulator inhibitors. At present，the under－standing of 2019-nCoV is still very limited. It is believed that with the continuous advancement of research，we can better understand the pathogenic mechanism of the virus and develop more efficient antiviral drugs.