Clinical analysis of perinatal COVID-19 in eight pregnant women

Abstract:

Objective：To explore and analyze the clinical characteristics and maternal-neonatal outcome of perinatal coronavirus dis－ease 2019（COVID-19）. Methods：Clinical data of eight pregnant women who were confirmed with COVID-19 in our hospital from 19th January to 9th February，2020 were retrospectively analyzed. Outcomes were followed up until March 6，2020. General characteristics，clinical features，and maternal and neonatal outcomes were analyzed. Results：①The average age of eight patients was （31.50±2.67） years old，including six multiparas and two primiparas. Six patients experienced onset of illness in late pregnancy，while two in puer－perium. ②Eight patients were in mild situation，with moderate-low temperature（6/8），cough，expectoration（4/8），chest tightness，dizzi－ness，myalgia，and vomiting（1/8）；decreased percentage of lymphocytes（6/8），decreased lymphocytes（3/8） and elevated aminotrans－ferase concentrations（2/8）；positive lung CT（7/8）. ③The range of gestational weeks of delivery was 36+5 to 40+6 weeks. Seven patients had a cesarean section and one had a vaginal delivery. Eight livebirths were recorded. No neonatal asphyxia was observed in newborns. The 36h nasopharyngeal swab in one newborn showed positive COVID-19. Conclusion：Most of patients with perinatal COVID-19 are mild or normal，and short-term maternal and neonatal outcomes are good. Other clinical manifestations are not typical，similar to the non-pregnant. It remains unclear whether COVID-19 can transmit vertically through placenta and consequently lead to short-term or long-term harm to neonates，and data need to be further accumulated.