Clinical characteristics and laboratory features of patients with coronavirus disease 2019 in Jiangbei District of Chongqing

Abstract:

Objective：To retrospectively analyze the clinical data and laboratory data of patients with coronavirus disease 2019 （COVID-19） and suspected patients in Jiangbei District of Chongqing，so as to provide scientific basis for formulating prevention and control strategies and measures. Methods：From January 24 to March 21 in 2020，data of 21 COVID-19 patients with positive nucleic acid and 21 suspected patients with highly doubtable CT and nucleic acid who were diagnosed in our hospital were collected. The ba－sic information，epidemiology，clinical features，laboratory results，CT results and post-discharge follow up in different groups were ret－rospectively analyzed. Results：Among the 42 patients，9 patients（9/42，21.4%） came back from Hubei province，19 patients（19/42，45.2%） had history of diagnosed patients 14（14/42，33.3%） had no history of communicable disease，with significant difference between two groups（P<0.001）. The median age was（44.48±16.49） years old; the ratio of males was 59.5% and of females was 40.5%. Common symptoms at onset were fever，cough and fatigue，but 5 patients had no clinical symptoms. Compared with the suspected diagnosed group，white blood cell count（WBC），neutrophil count（NEU），lymphocyte count（LYM），lymphocyte percentage（LYM%） and neu－trophil percentage（NEU%） were decreased significantly in the diagnosed group. 19.0% COVID-19 patients had a lower Patients with decreased WBC<3.5×109/L ratio in the diagnosed group were higher than those in the suspected group（19.0%） and pa－tients with NEU≥6.3×109/L ratio in the suspected group were higher than those in the diagnosed group（33.3%），with signifi－cant difference（P<0.05）. Among 42 patients，41 patients had CT changes（97.62%）. During the follow up，3 diagnosed patients were rechecked for nucleic acid-positive，which was not happened a－mong suspected patients；2 diagnosed patients had chest pain；CT of 26 patients（61.9%） suggested that lung lesions were basically ab－sorbed，without statistically significant differences between two groups. Conclusion：There are significant differences in epidemiological history between two groups. Therefore，we should detect the nucleic acid，serum IgM-Ab/IgG-Ab and chest CT of patients who has epidemic history or suspected contact history as soon as possible. Clinical symptoms of the COIVD-19 patient have no specificity，to some extent，some asymptomatic patients exist. Compared with suspected patients，the descended data level of WBC，LYM，LYM%，NEU% and NEU can be taken as diagnosed evidence According to the post-discharge follow-up，it is found that some COVID-19 patients are rechecked for nucleic acid-positive and have chest pain，suggesting that confirmed and suspected patients should recheck for nucleic acid，so as to strengthen the prevention and treatment of possible sequela.