Analysis of laboratory characteristics of 215 patients with COVID-19in Jiangxi Province

Abstract:

Objective：To analyze the clinical manifestationsand laboratory detection characteristics of 215 patients with coronavirus disease 2019（COVID-19） treated in Jiangxi Province and to provide evidence for the management of COVID-19 cases in these types. Methods：This study enrolled 215 patients with COVID-19 who were treated in The First Affiliated Hospital of Nanchang University from January 26 to February 24，2020. The clinical data of patients after admission were collected and laboratory tests such as blood routine，C-reactive protein（CRP），liver function profile（alanine aminotransferase-ALT，aspartate transaminase-AST，total bilirubin-Tbil，direct bilirubin-Dbil，total protein-TP，albumin-ALB），kidney function profile（creatinine-Cr，Urea，uric acid-UA），alkaline phosphatase（AKP），γ-glutamy transpeptidase（γ-GT） and myocardial enzymes（lactate dehydrogenase-LDH，creatine kinase-CK） were reviewed. The data of common and severe/critical patients were compared. Results：There were 165 cases of common patients（95 males and 70 females）；50 cases of severe/critical patients（36 males and 14 females）. The median age of common patients was 43 years old and 21.21% had comorbidities. The median age of severe/critical patients was 52 years old and 66% had comorbidities. The total number of white blood cells，the percentage of neutrophils，and the mean CRP in severe/critical patients were higher than those of common patients；the average values of lymphocyte percentage，red blood cells and hemoglobin in severe/critical patients were lower than those of common patients. There was no significant difference in liver function profile between severe/critical patients and common patients. The mean value of protein detection（TP 65.23 g/L；ALB 32.1 g/L） in severe/critical patients was significantly lower than thatin common patients（TP 71.53 g/L；ALB 45.3 g/L）；renal function profile test indicators（Cr 126.5 μmol/L；Urea 6.38 mmol/L；UA 302.5 μmol/L） and γ-GT（79.6 U/L） in severe/critical patients were higher than the corresponding index in common patients（Cr 55.75 μmol/L；Urea 4.46 mmol/L；UA 260.2 μmol/L；γ-GT 58.5 U/L）. Myocardial enzymes were not abnormal in COVID-19 patients. Conclusions：Severe/critical patients with COVID-19 in Jiangxi province had more medical comorbidities and more severe systemic inflammatory response than common patients.In ad－dition，oxygen carrying capacity，nutritional status，and renal function of the severe/critical patients were significantly worse than those of common patients.