Characteristics of hepatic damage in patients with coronavirus disease 2019

Abstract:

Objective：To analyze the characteristics of hepatic damage in patients with coronavirus disease 2019（COVID-19）. Methods：Clinical data of 90 patients with COVID-19 from January 21，2020 to February 20，2020 were analyzed retrospectively. The causes and characteristics of hepatic damage in COVID-19 were analyzed and summarized. Results：Among 90 patients，33 had hepatic damage，with the rate of 36.7%. The average time of hepatic damage was 9.0±6.1 days. The rate of hepatic damage in the mild group was 32.5% and in the severe group was 61.5%，showing a statistical difference（P<0.05）. BMI in the mild group was （24.3±2.3） kg/m2 and in the severe group was （22.7±3.6） kg/m2，with significant difference（P<0.05）. There was no statistical difference between hepatic damage and gender，age and the underlying liver disease（P>0.05）. Conclusion：The hepatic damage in COVID-19 patients is mainly mild，which is related to the primary disease，the severity of the disease and BMI，The drug and the underlying liver disease may play a certain promoting role. With the improvement of the primary disease，the liver injury is gradually improved，with good prognosis.