Correlation between blood uric acid and osteoporosis and its regulation mechanism

Abstract:

Objective：To investigate the correlation among redox state，uric acid metabolism and bone density of lumbar spine，and to preliminarily discuss the mechanism of uric acid on bone density. Methods：Healthy people without basic disease receiving physical examination in our hospital were selected，their medical history was recorded，and the BMI was calculated by measuring the height and weight. Elbow venous blood was collected on an empty stomach and biochemical indexes such as blood uric acid were detected by automatic biochemical analyzer. The correlation between uric acid metabolism and bone density was determined by SPSS 23.0 software. The osteoblastoma cell line MG-63 was treated with uric acid and hydrogen peroxide to analyze the cell activity，preliminarily discussing the role of uric acid in influencing bone density. Results：Compared with the normal bone mass group，the blood uric acid was significantly lower than that in the osteoporosis group，while the cholesterol was negatively correlated with bone density. Hydrogen peroxide significantly promoted osteoblast apoptosis in the cell experiment；uric acid，as an endogenous antioxidant，was able to re－verse the apoptosis-inducing effect of hydrogen peroxide. Conclusion：Uric acid metabolism is closely related to bone density，and may be related to the body’s redox status.