Analysis of risk factors influencing the prognosis of full-term and preterm infants with necrotizing enterocolitis

Abstract:

Objective：To investigate risk factors influencing prognosis of neonatal necrotizing enterocolitis（NEC） in full-term infants and preterm infants. Methods：The clinical data of 287 NEC patients（BELL stage≥Ⅱ） were retrospectively analyzed and divided into full-term group（n=128） and the preterm group（n=159） according to gestational age. and then use The univariate and multivariate logistic regression analysis was used to summarize risk factors influencing NEC prognosis in full-term and preterm infants. Results：NEC analysis in the full-term group showed that Ⅲ-stage NEC（OR=63.052，95%CI=2.373-1674.987，P=0.013） and complication of respiratory failure（OR=85.917，95%CI=3.005-2456.151，P=0.009） were independent risk factors for prognosis；probiotics（OR=0.036，95%CI=0.002-0.809，P=0.036） was protective factor. NEC analysis in the preterm group showed that sepsis（OR=5.669，95%CI=1.829-17.569，P=0.003） was independent risk factor influencing prognosis，and probiotics（OR=0.172，95%CI=0.054-0.547，P=0.003） was protective factor. Conclusion：There are some differences in risk factors of NEC prognosis in preterm and full-term infants，and clinical treatment should be individualized to improve prognosis.