Potential function and significance of autophagy on the immunosuppression of severe acute pancreatitis

Abstract:

Severe acute pancreatitis（SAP） is one of the common abdominal emergencies，which is often characterized by severe con－dition，high mortality and poor prognosis. However，immunosuppression plays a promoting role in SAP progression. Autophagy，as a cel－lular activity，not only participates in the activation of trypsinogen during SAP，but also significantly influences the immune system. In different stages of SAP，immune cells and autophagy demonstrates different forms. This paper reviewed the potential function and sig－nificance of autophagy in SAP immunosuppression.