Influence of intraoperative fluid replacement on postoperative outcomes in pediatric patients with neonatal necrotizing enterocolitis

Abstract:

Objective：To evaluate the relationship between intraoperative crystalloid administration and postoperative outcomes in pe－diatric patients with neonatal necrotizing enterocolitis（NEC）. Methods：A total of 172 NEC patients undergoing surgery from January 2012 to September 2018 in our hospital were retrospectively analyzed and were divided into the low crystalloid group[<25.89 mL/（kg·h）] and the high crystalloid group[>25.89 mL/（kg·h）] by taking median after correcting input crystalloid amount as standard. First time to enteral feeds，first defecation，the incidence of complications，the postoperative length of NICU or ICU stay，postoperative death and incomplete enteral nutrition within 90 days after surgery were monitored and compared. Results：The univariate analysis showed that the incidence of postoperative complications was significantly different in two groups（P<0.05）. Variables with P<0.05 in univariate analysis were included in stepwise backward logistic regression analysis and it was identified that crystalloid administration was an independent protective factor of postoperative complications（OR=0.955，95%CI=0.914－0.997，P=0.036）. Conclusion：The intraopera－tive crystalloid administration can reduce the risk of postoperative complications.