Differential expression of microRNA in patients with nontraumatic osteonecrosis of femoral head

Abstract:

Nontraumatic osteonecrosis of femoral head（NONFH） is characterized with disruption of blood supply to bone tissue and osteocyte necrosis，which is caused by a variety of risk factors. Due to its nontypical early symptoms and difficulties in diagnosis，pa－tients suffer hip joint pain and limited mobility in the late stage caused by femoral head collapse and the hip replacement will be the only choice in the final stage. Therefore，to seek for early diagnosis and treatment of NONFH has significance in early diagnosis and treatment. MicroRNA（miRNA） is a non-coding single-stranded RNA molecule that can involve in post-transcription regulation. With more advanced research techniques of miRNA and more studies on NONFH，more miRNAs are found that abnormally expressed in NONFH. This article summarized the differentially expressed miRNAs in different tissues and cells of NONFH，which has been re－ported by several studies and has consistency with those studies，and reviewed functions of these miRNAs and corresponding mecha－nisms for participating in pathogenesis.