Research analysis of the differential target genes of myocardial infarction and unstable angina pectoris based on bioinformatics

Abstract:

Objective：To explore the biological mechanism of myocardial infarction and unstable angina pectoris，so as to provide a direction for clinical researchers. Methods：Gene chip GSE29111 was extracted based on GEO database，differential target genes were screened on the basis of GWAS database，and all were analyzed via bioinformatics. Results：A total of 188 differential target genes identified by GEO database GEO2R had significant differences in protein expression（P<0.05）. After gene/region P value setting of -log10P≥3 in GWAS database，a total of 7 target genes related to myocardial infarction and unstable angina pectoris were screened，including MACF1，TANC2，PSMF1，CD59，MYO18B，GALNT10 and TFPI. Metascape annotation tool was used and it was found that 7 differential target genes were mainly related to the negative regulation of proteolysis and wound healing. The David tool was used to perform the online GO analysis and KEGG analysis of 7 differential target genes and it was showed that these differential target genes were related to the negative regulation of endogenous peptidase activity，coagulation，endogenous peptidase inhibitor activity，actin binding and complement system. Conclusion：Differential target genes of myocardial infarction and unstable angina pectoris are mainly related to the activity of endopeptidase inhibitors and complement system，and main regulated differential target genes are CD59 and TFPI.