Advances of cyclin B1 in malignant tumors

Abstract:

Cyclin B1（CCNB1） plays a key role in regulating the G2/M phase of the cell cycle and studies gradually have shown that CCNB1 is expressed in many malignant tumors and participates in the growth，differentiation，apoptosis and metastasis of tumor cells.CCNB1 is differentially expressed in different types of tumors，and its expression changes affect the development，treatment and prog－nosis of tumors. In this paper，the research progress of CCNB1 in tumor at home and abroad was reviewed.