Diagnostic value of serum CD147 level in ovarian cancer and its effect on prognosis and recurrence

Abstract:

Objective：To investigate the diagnostic value of serum extracellular matrix metalloprotein inductor（CD147） in ovarian cancer and its effect on prognosis and recurrence. Methods：A total of 110 ovarian cancer patients，60 ovarian benign diseases patients and 50 healthy people were collected. Levels of serum CD147 were tested by ELSIA，and were compared among three groups；Serum CD147，CA125 and HE4 were compared；correlation of serum CD147 with clinical course，histology，pathologic stage，clinical stage，recurrence rate and progression-free survival（PFS） was analyzed. Results：The level of serum CD147[（137.61±86.06） pg/mL] in the ovarian cancer group was higher than that in the benign disease group and the healthy group. The sensitivity，specificity and AUC of serum CD147（72.3%，93.8% and 0.882） were similar to those of CA125 and HE4，without significantly statistical differences（P>0.05）. Levels of serum CD147，CA125 and HE4 after six chemotherapy courses were significantly lower than those before the therapy （P>0.05），and showed significant positive correlation both before and after six chemotherapy courses（r=0.321，r=0.415，P<0.01）. Levels of serum CD147 before and after six chemotherapy courses had no statistical difference in age，tumor size，menopausal status，production time，histological type，menophania age of ovarian cancer patients（P>0.05），but had significant differences in FIGO staging，pathologic stage，infiltration，lymphatic metastasisand numbers of metastases（P<0.05）. Levels of serum CD147 before therapy and after six chemotherapy courses were significantly correlated with recurrence rate and progression-free survival（χ2=22.275，log-rank=20.400，P<0.01）. Conclusion：The serum CD147 has certain significance for diagnosing ovarian cancer and its expression level is closely related to the malignancy degree，invasion，metastasis，prognosis and recurrence of the tumor. Dynamic observation of the expression level of serum CD147 can be a reference index for diagnosing ovarian cancer，selecting surgical methods，evalu－ating therapeutic efficiency and monitoring prognosis.