Clinical application and research progress of fluorescein in the operation of glioma

Abstract:

Glioma is the most common primary malignant tumor in the central nervous system，with poor prognosis and high morbidity and mortality. It has been confirmed that the maximum excision of tumors within a safe range is beneficial to extend progression-free survival and overall survival，and improve patients’ prognosis. Fluorescence guided technique（FGT） can realize the visualization of the edge of brain glioma during operation by using fluorescent imaging reagent，so as to assist the surgeon in more accurate tumor re－section within the safe range. At present，the fluorescence imaging reagents used in clinic include sodium fluorescein（SF），5-aminolevulinic acid（5-ALA），indocyanine green（ICG），hypericin，talaporfin sodium（TPS），etc. In addition，a large number of new fluorescent agents are actively used in clinical or preclinical trials. This paper reviewed various intraoperative fluorescence imaging reagents for gliomas.