Effect of canagliflozin on heart failure

Abstract:

Canagliflozin，an active small molecule sodium-glucose co-transporter type 2（SGLT2） inhibitor，become a hot topic to treat diabetes mellitus because of their unique mechanism. Canagliflozin not only decreases plasma glucose level and HbA1c，but also has some extra therapeutic benefits，such as losing the body weight，lowering blood pressure，suppressing inflammatory response and improving cardiovascular outcomes，so as to suggest its direct or indirect protective effect on heart failure. Heart failure is one of the most common end-events of diabetes mellitus，which brings a promising application in heart failure. This article reviewed the possible mechanism of the effect of canagliflozin on heart failure.