Changes of left atrial diameter and NT-proBNP in patients with COX-MAZE Ⅳ procedure concomitant valvular surgery

Abstract:

Objective：To access the changes of left atrial diameter and NT-proBNP in patients with COX-MAZE Ⅳ procedure con－comitant valvular surgery. Methods：A total of 50 patients were consecutively recruited and divided into 3 groups：sinus group，AF-sinus group，AF-AF group. Left ventricular ejection fraction（LVEF） and left atrial diameter were measured by echocardiography before and 6 months after procedure. Plasma NT-proBNP levels were measured before and 6 months after procedure. Results：The left atrial di－ameters before procedure were significantly different between sinus group and AF group [（53.53±9.48） mm vs. （41.11±6.31） mm，P=0.000]. The plasma NT-proBNP levels were also significantly different [（2 792±1 582） pg/mL vs. （1 035±833） pg/mL，P=0.000]. But the LVEF values were not [（52.53±7.03）% vs. （58.00±5.87）%，P=0.07]. The left atrial diameters before procedure were different between AF-sinus group and AF-AF Group [（49.90±1.70） mm vs. （58.85±9.92） mm，P=0.007] and the plasma NT-proBNP levels were also differene [（2 298±261） pg/mL vs. （3 514±1 892） pg/mL，P=0.03]. The LVEF values were not [（53.37±1.49） % vs. （51.31±7.83）%，P=0.424]. The left atrial diameters after 6 months procedure were different between AF-sinus group and AF-AF group[（41.84±1.12） mm vs. （48.23±8.12） mm，P=0.009] and the plasma NT-proBNP levels were different [（489±84） pg/mL vs. （1 408±1 176） pg/mL，P=0.017]. The LVEF values were also different [（5408±5.47）% vs. （58.58±0.62）%，P=0.04]. Conclusion：The left atrial diameters and the plasma NT-proBNP levels are the risk factors of occurrence of AF in patients with valvular diseases. The more left atrial diameters and the plasma NT-proBNP levels before procedure tend to AF recurrence and the less left atrial diameters and the plasma NT-proBNP levels，the more LVEF values are beneficial to sinus rhythm restoration.