Association of impaired fasting glucose with 10-year atherosclerotic cardiovascular disease risk

Abstract:

Objective：To investigate the association of impaired fasting glucose（IFG） and fasting blood glucose（FBG） levels with the risk of cardiovascular disease based on the latest 10-year atherosclerotic cardiovascular disease（ASCVD） risk assessment model. Methods：The study enrolled 362 subjects with FBG measurement results from those patients who visited our internal medicine outpa－tient and wards of our hospital，and those who came to our hospital for physical examination，between July 2015 and April 2017，a－mong which 87 subjects in IFG status. The IFG is defined according to the definition of diabetes reported by the World Health Or－ganization in 1999（6.1 mmol/L≤FBG<7.0 mmol/L）. The estimated 10-year ASCVD risk score was calculated through the computa－tional equations given by the American Heart Association（ACC/AHA） Practice Guidelines Working Group. Results：Compared with people with normal glucose metabolism，statistical analysis showed that IFG people had higher body mass index，systolic blood pres－sure，diastolic blood pressure，FBG，and triglyceride levels（P<0.05）. Multivariate logistic regression indicated that，the IFG people was significantly associated with an increased risk of at 10-year ASCVD（≥7.5%）[OR：95%CI=4.41（1.78-10.93），P=0.001] compared to people with normal fasting glucose. FBG level was closely related to 10-year ASCVD risk score. With the increase of FBG level，the 10-year ASCVD risk gradually increased，especially when the FBG was higher than 5.7 mmol/L，the 10-year ASCVD risk was signifi－cantly increased（≥7.5%）. Conclusion：Based on the latest published 10-year ASCVD risk assessment equation，the study has found that both IFG and FBG levels are significantly associated with an increased risk of cardiovascular disease.