Abstract:With the development of antibiotics, the threat generated by infectious diseases has been successfully relieved. Clinicians could lock the criminal pathogen and apply corresponding treatment under the help of current testing methods like NGS and drug sensitive test. The central nervous system has been one of the commonest sites where intensive or refractory infections occur due to its special anatomic and physiologic characters. Among all the CNS infections, the perimeningeal infections which happens to or around the dura are thought to related with peripheral infections most closely as for their special etiology and pathophysiology. Although perimeningeal infections are usually caused by some anteceded infections, but their insidious course and unspecific manifestations make them hard to be diagnosed in time. Once perimeningeal infections begin to show apparent symptoms, serious damage could have been done to the CNS, which could not be cured by simple antibiotic therapies. Therefore, early recognition and diagnosis of perimeningeal infections with corresponding antibacterial treatment is the most important way to avoid poor prognosis caused by these curable neurological disorders, and at the same time, it can reduce the damage of unnecessary surgical intervention to the body.
