Abstract:Objective: To investigate the correlation between the susceptibility of rs1372525 and rs3822086 polymorphisms of αsynuclein gene (SNCA) and Parkinson's disease in Xinjiang. Methods: A case-control study was conducted to collect the peripheral blood of 225 outpatients with Parkinson's disease from the Affiliated Hospitals of Xinjiang Medical University and 231 healthy subjects matched with age, gender and place of birth. The patients were divided as the case group and the control group. The peripheral blood of two groups of participants were collected, and the polymorphism of SNCA rs1372525 and rs3822086 loci were analyzed by deoxyribonucleic acid (DNA) amplification and polymerase chain reaction (PCR). Results: The SNCA rs1372525 loci of the case group and the control group were respectively detected in 161 and 164 cases of AA type, 54 and 61 cases of AG type, and 10 and 6 cases of GG type. The frequency of allele A was 83.6% and 84.2% respectively, and the frequency of allele G was 16.4% and 15.8%. There was no significant difference in the distribution frequency of genotypes and alleles between the case group and the control group (P>0.05). There were 47 and 73 cases of CC type, 115 and 113 cases of CT type and 63 and 45 cases of TT type detected at rs3822086 locus in case group and control group, respectively. The frequency of allele C was 46.4% and 56.1%, and the frequency of allele T was 53.6% and 43.9%, respectively. There was no significant difference in rs3822086 CC genotype and allele C between the two groups (P>0.05). However, there were significant differences in the distribution frequency of CT and TT genotypes and allele T between the two groups (P<0.05). Conclusion: There is no correlation between SNCA rs1372525 locus polymorphism and the incidence of Parkinson's disease, and rs3822086 locus is considered as one of the susceptible sites in the occurrence and development of Parkinson's disease.
