Cambridge semantic memory test battery applied research among patients with semantic dementia

Abstract:

Objective: To detect the application of the Cambridge semantic memory test battery (CST) in patients with semantic dementia (SD). Methods: In the study, 26 SD patients and 25 normal control subjects were given language scales and other tests including mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA). Results: ①The overall evaluation results of the SD group were worse than those of the normal control group (P<0.001). ②The AUC values of the 4 subtests of CST in the detection of SD patients and the normal control group were 0.984 (95%CI=0.951-1.000), 0.915 (95%CI=0.826-1.000), 0.898 (95%CI=0.808-0.988), 0.857 (95%CI=0.733-0.980) (P<0.001). ③Bivariate analysis of CST results and MMSE, MoCA, comprehensive cognitive assessment, activity of daily living scale (ADL), clinical dementia rating scale (CDR) and other results had significant correlation at the 0.01 level (P<0.001). ④SD patients had significant atrophy of the anterior lower part of the temporal lobe, and focused on the left side, which was consistent with the evaluation results of the relevant neuropsychological scale. Conclusion: CST can be used to screen SD patients.