Abstract:With the aging of the population, the incidence of neurodegenerative diseases such as Alzheimer's disease (AD) is rising year by year. Cognitive impairment and neuropsychiatric symptoms are typical manifestations of AD. Cognitive impairment is mainly manifested in the decline of memory, logical ability, language ability, executive ability and attention. Neuropsychiatric symptoms mainly include depression, euphoria, apathy and so on. The above symptoms can affect the patient's daily living ability and quality of life. At present, there is no cure for AD, so early detection, diagnosis and treatment are of great significance for delaying the progression of the disease, improving the quality of life of patients, and reducing the burden on caregivers and society. At present, the cognitive assessment of AD is mainly based on neuropsychological scale test, but this method still has many disadvantages. This review focuses on the latest advances in cognitive assessment based on virtual reality (VR), which aims to provide more reliable diagnosis for home or clinical settings.