Abstract:Alzheimer's disease (AD) is one of the main causes of dementia, and subjective cognitive decline (SCD) is considered as the pre-clinical stage of AD. Early diagnosis of SCD is of great significance to the prevention and treatment of AD. Among various diagnostic methods of SCD, biochemical diagnosis is one relatively simple, low cost and less invasive. The combination of biochemical diagnosis and neuropsychological assessment has a good prospect in the diagnosis of SCD. Therefore, this paper has reviewed the research on cerebrospinal fluid, plasma, urine and other biochemical detection methods of SCD.
