Research progress of gut microbiota and its metabolites as diagnostic biomarkers of Alzheimer's disease

Abstract:

Alzheimer's disease (AD) is the main cause of senile dementia. With the proposal of the "brain-gut axis" theory, more and more studies have confirmed the occurrence and development of AD are closely related to the change of gut microbiota and its metabolites. This article reviews and discusses the changes of fecal gut microbiota and its metabolites occurred in AD. Besides, the application prospects of fecal gut microbiota and its metabolites as AD diagnostic biomarkers are described.