Advances in the study of hippocampal subregion in Alzheimer's disease

Abstract:

Alzheimer's disease (AD) is a progressive neurodegenerative disease. The hippocampus is the earliest and highly specific marker in the pathogenesis of AD, which can be divided into CA1-4 subregions. The hippocampal subregion is involved in the processing of episodic memory, social memory and associative memory, and is associated with aging, Aβ deposition, hyperphosphorylation of tau protein, ischemia and other influencing factors. The study of the changes in the hippocampal subregion in AD is of great clinical significance for the early identification and diagnosis of AD, and may provide new ideas for the treatment of AD.