Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients

Abstract:

Alzheimer's disease (AD) and its risk population of mild cognitive impairment (MCI) are the most common cognitive impairments, whose core impairment is episodic memory dysfunction. The default network (DMN) is composed of the core subsystem (Core), the dorsal medial prefrontal cortex (DMPFC) subsystem and the medial temporal lobe (MTL) subsystem. The three subsystems cooperate with each other to maintain the steady state of episodic memory function. However, the patterns of interaction of these subsystems in AD spectrum patients are not clear yet. In this study, we will systematically review the advances of neuroimaging studies in this field, and the specific impairment characteristics of AD spectrum patients, which will provide important ideas for early screening, progression monitoring, efficacy evaluation and differential diagnosis of AD spectrum diseases.