Risk factors of residual headache after cerebral venous sinus thrombosis

Abstract:

Objective：To analyze the related risk factors of residual headache in patients with cerebral venous sinus thrombosis（CVST）. Methods：The study retrospectively analyzed the clinical data of CVST patients who met the inclusion criteria and had complete medical records admitted to The Second Hospital of Bazhou from January 2016 to June 2019，and analyzed the related risk factors of residual headache in CVST patients using univariate and multivariate logistic regression methods. Results：A total of 111 CVST patients met the inclusion criteria，of which 38（34.23%） patients had residual headache. The univariate analysis showed that there were significant differences in the past history of headache（Z=-3.723，P=0.000），delayed anticoagulation（Z=-3.519，P=0.000），and the failure of venous sinus recanalization（Z=-3.071，P=0.002） between the residual headache group and the non-residual headache group. Multivariate regression analysis found that the failure of venous sinus recanalization was a risk factor for residual headache（OR=6.419，95%CI=1.922-21.438，P=0.003）. Secondly，delayed anticoagulation（delayed for more than 7 days） increased the risk of residual headache（OR=5.248，95%CI=1.710-16.105，P=0.004），and past headache history was also an independent risk factor for residual headache（OR=11.98，95%CI=2.451-53.931，P=0.002）. Conclusion：Venous sinus recanalization，delayed anticoagulation and past headache history are independent risk factors of residual headache in CVST patients. Timely anticoagulation and recanalization of cerebral veins in patients with CVST may be of great significance to reduce the occurrence of residual headache.