Importance of trace amine receptor 1 in pathogenesis of Gilles de la Tourette syndrome

Abstract:

Trace amine receptor 1（TAAR1） is a new member of the G protein-coupled receptor（GPCR） family which was discov－ered in 2001. Related studies have found that trace amine（TA） is highly sensitive and can mediate TA regulation of the activity of dopamine（DA） neurons. TAAR1 itself is also a regulator of the DA system，which is closely related to the normal function of the DA system. The disorder of DA energy system can also lead to Gilles de la Tourette syndrome（TS）. Therefore，TAAR1 provides a new target and direction for exploring the pathogenesis of TS.