Expression of Bcl-2 and c-Myc oncogenes and P53 and P16 anti-oncogenes in early development-arrest-embryo tissue

Abstract:

Objective：To explore the differential expression of oncogenes and anti-oncogenes in early development-arrest-embryo tissue and normal early embryonic tissue. Methods：The expression of Bcl-2 and c-Myc oncogenes and P53 and P16 anti-oncogenes in chorionic tissue were analyzed by immunohistochemical method from 56 cases of normal early embryonic tissue and 68 cases of early development-arrest-embryo tissue. Results：The positive rates of Bcl-2 and c-Myc oncogenes in normal early embryonic tissue and early development-arrest-embryo tissue were 53.57%（30/56） vs. 30.36%（17/56） and 77.94%（53/68） vs. 45.59%（31/68） respectively. The positive rates of P53 and P16 anti-oncogenes in normal early embryonic tissue and early development-arrest-embryo tissue were 39.29%（22/56） vs. 73.21%（41/56） and 27.94%（19/68） vs. 47.06%（32/68） respectively. Conclusion：The balanced expression of oncogenes and anti-oncogenes plays an important role in early embryonic development.