Gastric oxyntic gland tumour（chief cell predominant type）：report of 9 cases and literature review

Abstract:

Objective：To assess the clinicopathological features of gastric oxyntic gland tumour chief cell predominant type（GOGT-CCPT）. Methods：Clinicopathologic characteristics of 9 patients with GOGT-CCPT admitted to Ya’an People’s Hospital from December 2017 to July 2020 were collected in the study. The endoscopic features，pathological features and immunohistochemical results were analyzed，and the relevant literatures were discussed. Results：Among the 9 patients，5 were female and 4 were male，with a median age of 54 years，including 6 cases of gastric adenocarcinoma of fundic gland type（GA-FG） and 3 cases of gastric oxyntic gland adenoma（GOGA）. The most common symptom was abdominal pain（5/9）. Gastroscopy revealed an elevated（8/9） or flat（1/9） lesion in the gastric corpus and the gastric fundus，with a diameter of 2 to 6 mm. Clinicopathological examination showed that the tumor was mostly located in the lamina propria，and both GA-FG and GOGA were mainly composed of chief cells，but there were also scattered parietal cells and mucous neck cells，with mild atypia and arranged in irregular glandular patterns. Peritumor space（5/6） and fibrosis（1/6）could be found among GA-FG cases. Immunophenotype showed that pepsinogen Ⅰ was expressed in chief cells，H+-K+-ATPase in parietal cells and mucin 6 in cervical mucus cells. Four patients had a follow-up for 12-25 months，without any recurrence. Conclusion：GOGT-CCPT is a rare tumor with a distinct clinicopathologic features and a favorable prognosis.