Correlation between early seizures in patients with cerebral venous sinus thrombosis and serum D-dimer level

Abstract:

Objective To investigate the relationship between early seizures in patients with cerebral venous sinus thrombosis（CVST）and the serum D-dimer level，and discuss the effects on the prognosis.Methods The CVST patients who were treated in the wards of Neurological and Cerebrovascular Departments of The First Affiliated Hospital of Naval Medical University from November 2010 to March 2021 were reviewed，and the general information，diagnosis and treatment of CVST and related hematological indicators of the patients were collected. Then the patients were divided into two groups according to the presence or absence of early seizures，the differences of related indicators between the two groups were analyzed，and the influencing factors of early seizures were studied by logistic regression analysis. The patients were divided into good and poor prognosis group by modified Rankin scale（mRS） score，and the relationship between serum D-dimer level and prognosis of CVST patients was analyzed.Results A total of 60 patients with CVST were included，including 22（36.7%） with seizure and 38 without seizure. The results of comparing the baseline data and hematological indexes of the two groups showed that mRS score and D-dimer level in the seizure group were significantly higher than those in the non-seizure group，and the incidence of poor prognosis was significantly higher than that of the non-seizure group； logistic regression analysis showed that D-dimer level might be a risk factor for early seizures in CVST（OR=1.513，95%CI=1.022-2.241，P=0.039）；early seizures were related to the poor prognosis of CVST patients，and serum D-dimer level before and after treatment and its decreasing range were not significantly related to disease prognosis.Conclusion High serum D-dimer levels are associated with early seizures in CVST，and early seizures affect the prognosis of CVST patients. Therefore，early intervention in CVST patients with elevated serum D-dimer on admission is expected to prevent early seizures and improve outcomes of CVST patients.