Advances in effects of long noncoding RNA on regulating ischemia-reperfusion injury

Abstract:

Ischemia stroke（IS） has high morbidity and high mortality worldwide. As effective treatments for IS remain limited，a better new therapeutic intervention target is needed. Increasing evidence suggests that long noncoding RNA（LncRNA） has protective effect on cerebral ischemia-reperfusion injury，and it is expected to be a potential target for the treatment of IS. This paper has reviewed the protective effects and the mechanism of LncRNA on IS，so as to provide ideas for further clinical research on the related fields. Additionally，this paper has pointed out that it would be necessary to study whether LncRNA could induce intracranial hemorrhage transformation in IS before further applying it to clinical research，and it would be suggested to design dosage forms and administration methods suitable for human use.