Risk assessment of early acute kidney injury after coronary artery bypass grafting

Abstract:

Objective To investigate the association between the hemoglobin / red blood cell distribution width ratio（HRR）and early acute kidney injury（AKI）after coronary artery bypass grafting（CABG）.Methods All patients were enrolled from the Medical Information Mart for Intensive Care Database（MIMIC）-Ⅳ. The patients were divided into 2 groups according to whether AKI occurred. The general data of the 2 groups were compared and analyzed，the variables with statistical difference were included in logistic univariate regression analysis，and variables with P<0.05 were included in multivariate logistic regression analysis. Logistic regression model was used to evaluate the predictive value of HRR for AKI risk after CABG. Stratified regression model was used for subgroup analysis.Results A total of 5 623 patients were enrolled in the study，including 4 342 cases in the AKI group and 1 281 cases in the non-AKI group. The HRR level at admission in AKI group was significantly lower than that in non-AKI group（P<0.001）. Multivariate regression model showed that HRR was an independent risk factor for AKI after CABG（OR=0.92，95%CI=0.88-0.96，P<0.001）. Logistic regression model showed that in model Ⅲ（adjusting for potential confounders），low HRR level was still an independent influencing factor for AKI after CABG. Subgroup analysis found that the association between HRR and AKI was similar in most covariates.Conclusion Low HRR level is an independent risk factor for AKI after CABG.