Research progress on the role of SOCS-3 in liver diseases

Abstract:

Suppressor of cytokine signaling-3（SOCS-3） is a kind of cytokine signaling transduction inhibitory protein，involving in the regulation of multiple signal transduction pathways in vivo. It’s found that SOCS-3 plays an important role in the occurrence and development of liver fibrosis，viral hepatitis and liver tumors，and the antiviral efficacy of interferon is closely related to the genetic expression of SOCS-3. This review briefly summarizes the structure and molecular function of SOCS-3 and related research in liver diseases in recent years.