Regulatory mechanism of ferroptosis and its advances in liver diseases

Abstract:

Ferroptosis is a cell death mode caused by the excessive accumulation of iron dependent reactive oxygen species，which leads to the imbalance of redox. Genes related to iron metabolism and lipid peroxidation metabolism are involved in its regulation，and the regulatory mechanism is relatively complicated. Recent studies have reported the important roles of ferroptosis in liver diseases. This paper reviews the regulatory mechanism of ferroptosis and its research progress in liver diseases，with a view to providing a new direction for clinical treatment of such diseases.