Abstract:Objective: To summarize and analyze the data of thyroid function of patients with immunoglobulin 4-related disease (IgG4-RD) , so as to raise the clinicians' awareness on monitoring the thyroid function of patients. Methods: The clinical data of IgG4-RD patients who were hospitalized and diagnosed in Peking University First Hospital from July 2005 to September 2020 were collected through searching the electronic medical record retrieval system by using "immunoglobulin 4-related diseases" as the key word. We analyzed the thyroid function status and the changes before and after the treatment of IgG4-RD patients and the changes of thyroid function of some patients with follow-up data. Results: A total of 89 IgG4-RD patients (69 males and 20 females) were enrolled in the current study. Among 66 patients (74.2%) with thyroid function test results, 21 patients had thyroid dysfunction, including non-thyroid illness syndrome (NTIS, n=12) , subclinical or overt hypothyroidism (n=8) and central hypothyroidism (n=1) . Among them, 5 patients had the follow-up results, 3 patients got the normalization of thyroid function during the course of treatment and one patient remained subclinical hypothyroidism. And the decreased T3 level was improved in one patient with NTIS. Conclusion: Thyroid dysfunction is common in IgG4-RD patients, and NTIS is the main manifestation. The etiology of thyroid dysfunction in patients with IgG4-RD needs to be identified. The thyroid dysfunction may be restored in some patients with the treatment of IgG4-RD.
