Research progress on post-transcriptional mechanisms of parathyroid hormone gene expression regulation in secondary hyperparathyroidism

Abstract:

Secondary hyperparathyroidism (SHPT) is one of the most common severe complications in chronic kidney disease patients and characterized by elevated parathyroid hormone (PTH) . Studies have confirmed that PTH mRNA-related binding proteins and miRNAs regulate the stability and expression of PTH mRNA, thereby mediating its post-transcriptional regulatory mechanism and playing an essential role in the high level of PTH in SHPT. The potential clinical application value of post-transcriptional regulation in the diagnosis and treatment of SHPT remains further explored. This paper reviews the current progression in the post-transcriptional regulation mechanism of the PTH gene in SHPT.