Diagnosis and treatment status and research progress of the obstetric antiphospholipid syndrome

Abstract:

Antiphospholipid syndrome (APS) is an autoimmune disease affecting multiple organs and systems. The combination of APS with maternal hemodynamic changes during pregnancy can put the body in a hypercoagulable state, making it highly susceptible to placental thrombosis. In addition, the effect of antiphospholipid antibody (aPL) on trophoblast cell function can cause preeclampsia, fetal growth restriction, intrauterine fetal death, and other adverse outcomes. It is called obstetric antiphospholipid syndrome (OAPS) when patients with APS develop obstetric complications. This article provides a literature review on the diagnosis and staging of OAPS, the correlation with adverse pregnancy outcomes, the current status of diagnosis and treatment, and long-term follow-up, with the aim of providing guidance for clinical work.