Research progress of low-dose aspirin in obstetrics and assisted reproduction

Abstract:

Aspirin is a cyclooxygenase inhibitor with anti-inflammatory and anti-platelet properties. As indicated by several national guidelines, low-dose aspirin (LDA) use in obstetrics and assisted reproduction has recently increased, particularly for the prevention of preeclampsia. At the same time, LDA can effectively improve the placental hypoperfusion by inhibiting the activity of cyclooxyge-nase to exert the effect of anti-platelet aggregation, and its indications for fetal growth restriction, preterm birth, obstetric antiphospholipid syndrome, assisted reproductive technology, and other conditions have been gradually expanded. This article reviews the recommendations and research progress of various guidelines on the application of low-dose aspirin in obstetrics and assisted reproduction.