Abstract:Objective: To explore the best placement time and effect evaluation of dinoprostone suppository for full-term pregnancy induction with different Bishop’s cervical scores. Methods: Full-term pregnant women were divided into ≤3 groups, 4 groups and 5 groups according to Bishop’s cervical score. According to the placement time of dinoprostone suppository, each score group was divided into morning group (08:00-12:59) , afternoon group (13:00-17:59) and evening group (18:00-22:59) , and the effective rates of cervical ripening, stages of labor and pregnancy outcomes of all groups were retrospectively analyzed. Results: A total of 1 139 pregnant women were enrolled, and the effective rate of cervical ripening was 93.59%. The effective rates of cervical ripening were 95.75%, 92.93% and 90.12% in each group with cervical score ≤3, 4 and 5 points before induction of labor (P<0.05). In the effective group, the incidence of amniotic fluid fecal contamination was 11.07%, fetal distress was 1.13%, and postpartum hemorrhage was 2.16%. Among the vaginal delivery women, when the Bishop score of cervix was less than or equal to 3, the primipara’s time from delivery to vaginal delivery was the shortest (4.82 h, P=0.005). The time from parturient to vaginal delivery was also the shortest (4.01 h, P=0.044). There was no significant difference in other indexes between groups. Conclusion: Dinoprostolone suppository is safe and effective for induction of labor in full-term pregnancy. For pregnant women with cervical score≤3, dinoprostone suppository can be placed at night to induce labor. For those with cervical score > 3, it can be placed at a time when medical staff are energetic, convenient to operate and can observe closely.
