Abstract:As a common reproductive endocrine disease, premature ovarian insufficiency (POI) endangers women’s reproductive health and quality of life. Excessive apoptosis of ovarian granulosa cells has been confirmed to affect the development of follicles, which may be the pathogenesis of POI. It has been found that apoptosis of granulosa cells is related to PI3K/Akt/NF-κB signal pathway and the expression of apoptotic protein. Kidney-tonifying prescriptions can inhibit granulosa cell apoptosis, improve ovarian function, and regulate the expression of signal molecules related to PI3K/Akt/NF-κB signaling pathway. Therefore, combined with relevant literature reports, it is speculated that kidney-tonifying prescriptions may inhibit ovarian granulosa cell apoptosis by regulating PI3K/Akt/NF-κB signaling pathway to provide ideas and methods for basic research and clinical diagnosis and treatment of POI.
