Abstract:Even though the infection of hepatitis B virus (HBV) has been reduced by the vaccination and the improvement of human health awareness, and the gradual development of antiviral drugs. So far, the elimination of HBV is still a serious problem. Hence, the accurate detection rate of HBV is extremely important. The traditional serum makers HBV DNA and hepatitis B surface antigen (HBsAg) have certain limitations in assessing the anti-HBV efficacy and accurately reflecting the transcriptional activity of covalently closed circular DNA (cccDNA). In order to solve this situation, novel HBV serum markers have been developed, such as HBV surface antigen, HBV RNA, HBV core related antigen, and HBV large surface protein. Based on the different reference values of different markers in disease diagnosis, this article briefly summarizes the clinical applications and limitations of these markers, which aims to provide references for the efficient and accurate detection of HBV and clinical prognosis.
