Abstract:Diabetic nonhealing wounds are closely related to glycometabolism, which is a common clinical and intractable complication. Due to its complicated pathogenesis, safe and efficient treatments are still in needs. This article described its relevant pathogenesis, including "microenvironmental contamination", excessive oxidative stress, "hidden damage", and intestinal microbiological disorder, etc. In addition, the research progress of cytokines, hyperbaric oxygen, new materials and application of new drug were reviewed, in order to provide a theoretical basis for research and development of drugs and clinical treatment in this field.
