Association of a novel nutritional index with carotid artery disease

Abstract:

Objective To explore the association of triglycerides（TG）total cholesterol（TC）body weight（BW）index（TG×TC×BW index，TCBI）with carotid artery disease.Methods A total of 2 290 patients with suspected stable carotid artery disease who were hospitalized in a hospital of Ma'anshan City，Anhui Province from November 2016 to October 2019 were selected as the research subjects. All of them were divided into carotid artery disease group（n=1 352）and control group（n=938）according to the results of color Doppler detection. We collected the general demographic characteristics，clinical characteristics，color Doppler examination indexes and blood biochemical detection indexes. Regression models were established to analyze the relationship between TCBI and carotid artery disease.Results The TCBI of the carotid artery disease group（χ²=34.018，P<0.001）was higher than that of the control group；dyslipidemia（χ²=143.933，P<0.001）and diabetes（χ²=29.946，P<0.001），internal carotid artery resistance index（ICA-RI）（t=2.468，P=0.014），triglyceride glucose（TyG）index（t=9.160，P<0.001），intima-media thickness（IMT）≥ 1.0 mm（t=34.018，P<0.001）in the high TCBI group were higher than those of the low TCBI group. TCBI was positively correlated with dyslipidemia（r=0.510，P<0.001），ICA-RI（r=0.363，P<0.001）and atherogenic index of plasma（r=0.714，P<0.001）. In the correlation analysis，the TCBI>1 800 was an independent risk factor for carotid artery disease.Conclusion The TCBI has potential application value in the screening and clinical diagnosis of carotid artery disease.