Role of intestinal barrier in the occurrence and development of obesity related metabolic diseases

Abstract:

With the increase of the proportion of obese population，the incidence of obesity related metabolic diseases such as nonalcoholic fatty liver disease（NAFLD） and type 2 diabetes mellitus（T2DM） is increasing year by year，which brings a heavy burden to the family and society. A large number of experimental data confirm that intestinal barrier injury plays an important role in the occurrence and development of obesity related metabolic diseases. This paper summarizes the structure，function and evaluation methods of intestinal barrier in detail，and summarizes the research progress of intestinal barrier injury and obesity related metabolic diseases，so as to provide a theoretical basis for how to evaluate patients' intestinal barrier function and how to treat metabolic diseases by improving intestinal barrier function.