Research progress of TM6SF2 in nonalcoholic fatty liver disease

Abstract:

Nonalcoholic fatty liver disease（NAFLD） is a type of chronic liver diseases characterized by abnormal accumulation of triglycerides（TG） in the liver. Its incidence is increasing year by year，and it is the most common liver disease at present. Transmembrane 6 superfamily member 2（TM6SF2） is a member of the transmembrane protein superfamily. A large number of studies have confirmed that TM6SF2 plays an important role in the occurrence and development of NAFLD. This article reviews the role and possible mechanism of TM6SF2 in NAFLD.