Research progress of circular RNA in cancer metabolism

Abstract:

Cancer metabolic reprogramming caused by genomic instability is considered to be a unique marker of tumor，providing a necessary energy source for the rapid growth and proliferation of cancer cells. Circular RNAs are a class of noncoding RNAs with a closed circular structure. They can function by interacting with other RNAs or proteins to affect the protein level. Recently，increasing studies have shown that circular RNAs are involved in the regulation of cancer metabolic reprogramming. However，there are few reviews on the role of circular RNAs in cancer metabolism. Therefore，in this paper，we will systematically elaborate the relationship between circular RNA and cancer metabolism， providing a better theoretical basis for the diagnosis and treatment of clinical cancer.