Research advances of ferroptosis in Alzheimer's disease

Abstract:

Recent studies have shown that ferroptosis plays an important role in the occurrence and development of Alzheimer's disease. This article summarizes relevant domestic and foreign literature in recent years，and categorizes and reviews the relationship between the three main mechanisms of ferroptosis，namely iron metabolism disorder，glutathione（GSH） depletion，and lipid peroxidation，and AD. This finding suggests that ferroptosis may become a new therapeutic strategy to treat and prevent AD in the future.