Potential predictor of MRI peritumoral features in prognosis for colorectal liver metastases after non-anatomical hepatectomy

Abstract:

Objective To evaluate the potential long-term prognostic impact of peritumoral imaging features in patients with colorectal liver metastases（CRLM） after non-anatomic resection（NAR）.Methods Thirty-six patients who had abdominal gadoxetic acid-enhanced magnetic resonance imaging（MRI） before CRLM surgery were included in this retrospective research. Peritumoral early enhancement，peritumoral hypointensity on hepatobiliary phase（HBP），and biliary dilatation to the CRLM at MRI were evaluated. Survival estimates were calculated using the Kaplan-Meier method，and multivariate analysis was conducted to identify independent predictors of liver recurrence-free survival（LRFS）， recurrence-free survival（RFS） and overall survival（OS）.Results Overall， 36 patients with 58 CRLM were evaluated. There was a significant difference in 3-year LRFS and RFS rates between patients with and without peritumoral early enhancement（LRFS：14.3% vs. 43.9%，P=0.005； RFS：14.3% vs. 40.3%，P=0.006）. Peritumoral early enhancement was associated with poor LRFS［P=0.002， hazard ratio（HR）=5.541，95%CI=1.853-15.975］ and poor RFS（P=0.002，HR=5.392，95%CI=1.887-15.412） in patients with CRLM after NAR. However， bile duct dilatation and peritumoral hypointensity on HBP were not independent predictors of LRFS， RFS and OS.Conclusion In patients with CRLM after NAR， peritumoral early enhancement was predictor of LRFS and RFS.