Correlation between serum sterol regulatory element binding protein-2 and acute cerebral infarction

Abstract:

Objective To explore the correlation between serum sterol regulatory element binding protein-2（SREBP-2） and acute cerebral infarction（ACI）.Methods From October 2020 to March 2021，134 ACI patients were recruited as the ACI group and 34 healthy individuals were recruited as the control group. Serum SERBP-2 concentration was detected by enzyme-linked immunosorbent assay（ELISA） and subgroup analysis was conducted based on trial of Org 10 172 in acute stroke treatment（TOAST） classification and whether patients had diabetes mellitus. National Institutes of Health Stroke Scale（NIHSS） score was used to evaluate the disease severity of patients and the correlation between serum SREBP-2 and the severity was analyzed. The modified Rankin scale was used to assess the 90-day functional prognosis of the ACI group. The ACI patients were classified into favorable outcomes group and unfavorable outcomes group and serum SREBP-2 concentration of two groups were compared. Logistic regression was used to analyze whether serum SREBP-2 was related to ACI prognosis.Results Serum SREBP-2 concentration of the ACI group was significantly lower than that of the control group［72.60 （57.50， 83.35） ng/mL vs. 86.80（77.20，97.90） ng/mL，P=0.000］. The area under the curve for serum SREBP-2 concentration to identify patients with ACI and healthy people was 0.782（P=0.000）. Serum SREBP-2 concentrations of subtype of large artery atherosclerosis，cardio-embolism and small artery occlusion were all lower than that of the control group（P=0.000，P=0.003，P=0.000）. Serum SREBP-2 concentration of ACI patients with diabetes mellitus was higher than those without（P=0.021）. In the ACI group，serum SREBP-2 concentration was not correlated with the NIHSS score at admission（P>0.05）. Serum SREBP-2 concentration of the favorable outcomes group was lower than that of the unfavorable outcomes group，but the difference had no statistical significance（P>0.05）. Logistic regression analysis showed that serum SREBP-2 concentration was not associated with 90-day functional prognosis of ACI（OR=1.016，95%CI=0.991-1.042，P=0.205）.Conclusion Serum SREBP-2 concentration decreases significantly in ACI patients. Serum SREBP-2 has a certain efficacy in identifying patients with ACI and healthy people. However，serum SREBP-2 has no correlation with the severity and prognosis of ACI patients.